What are the Challenges Associated with Lipid Nanoparticles?
While LNPs offer significant advantages, there are challenges to their use in cancer therapy: 1. Manufacturing Complexity: The production of LNPs requires precise control over size, charge, and encapsulation efficiency, making the manufacturing process complex. 2. Stability Issues: LNPs can be unstable during storage and transport, which may affect their efficacy. 3. Distribution and Clearance: Ensuring that LNPs reach the intended target while avoiding rapid clearance by the immune system or liver can be challenging. 4. Regulatory Hurdles: As with any new therapeutic technology, LNPs must undergo rigorous testing to ensure their safety and efficacy, which can be a lengthy and costly process.
