As a tumor suppressor, CDKN1C prevents the unchecked proliferation of cells by inhibiting cell cycle progression. Loss of CDKN1C function can lead to increased cell division and tumorigenesis. Mutations, deletions, or epigenetic silencing of CDKN1C are observed in various cancers, including breast cancer, colorectal cancer, and lung cancer. Notably, CDKN1C is involved in the imprinting disorder Beckwith-Wiedemann syndrome, which is associated with an increased risk of childhood tumors, indicating its critical role in growth regulation.
