What Are the Implications of DSBs in Cancer Research?
Understanding DSBs and their repair mechanisms can pave the way for novel cancer therapies. For instance, inhibitors of PARP (poly ADP ribose polymerase), a protein involved in single-strand break repair, have shown promise in treating cancers with defective HR, such as BRCA-mutated breast and ovarian cancers. Additionally, biomarkers indicating defective DSB repair pathways can help in personalizing cancer treatment, making it more effective and reducing unnecessary side effects.
