TNFR1 (Tumor Necrosis Factor Receptor 1) is a receptor for the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α). It plays a crucial role in mediating the effects of TNF-α, including apoptosis, cell proliferation, and inflammation. TNFR1 is ubiquitously expressed in almost all tissues and is involved in various physiological and pathological processes.