What Therapeutic Strategies Target TNFR1 in Cancer?
Given its significant role in cancer, targeting TNFR1 has been considered a therapeutic strategy. Monoclonal antibodies and small molecules that inhibit TNFR1 signaling are being developed and tested in preclinical models. Additionally, modulating the downstream pathways activated by TNFR1, such as the NF-κB pathway, can also provide therapeutic benefits. However, due to the dual role of TNFR1, careful consideration is needed to avoid adverse effects.