TNFR1 can influence cancer development through multiple mechanisms. On one hand, the activation of TNFR1 can lead to apoptosis of cancer cells, thus acting as a tumor suppressor. On the other hand, chronic activation of TNFR1 can promote inflammation and support a microenvironment conducive to tumor growth and metastasis. This dual role makes TNFR1 a complex player in cancer biology.
