What are the mechanisms of CDKN1C deregulation in cancer?
CDKN1C deregulation in cancer can occur through several mechanisms. Genetic alterations such as mutations and deletions can lead to loss of function. Epigenetic changes, such as DNA methylation and histone modifications, can silence CDKN1C expression. Additionally, non-coding RNAs like microRNAs can downregulate CDKN1C, contributing to its decreased expression in tumors. These mechanisms highlight the complex regulation of CDKN1C and its impact on cancer development.
