What are the Challenges in Lead Optimization for Cancer Drugs?
Lead optimization in cancer research faces several challenges:
Heterogeneity of Cancer: Different types of cancer, and even different cells within the same tumor, may respond differently to treatment. Side Effects: Balancing efficacy with minimizing harmful side effects. Drug Resistance: Cancer cells can develop resistance to treatment over time. Complex Biology: Understanding and targeting the complex signaling pathways involved in cancer.
