What Factors are Considered During Lead Optimization?
Several factors are considered during the lead optimization phase:
Efficacy: The compound's ability to inhibit or kill cancer cells. Selectivity: The ability to target cancer cells specifically without affecting healthy cells. Pharmacokinetics: How the drug is absorbed, distributed, metabolized, and excreted in the body. Safety: Potential toxic effects and the therapeutic index. Stability: Chemical and metabolic stability of the drug. Formulation: The drug's delivery mechanism and bioavailability.
