lead optimization

What Techniques are Used in Lead Optimization?

A variety of techniques are employed during lead optimization, including:
Structure-Activity Relationship (SAR) studies to identify which chemical modifications enhance or reduce activity.
Computational Modeling to predict how changes in the chemical structure will impact biological activity.
High-Throughput Screening (HTS) to rapidly test large libraries of compounds.
In vitro and in vivo testing to assess the biological effects of the compounds.
ADMET profiling to evaluate Absorption, Distribution, Metabolism, Excretion, and Toxicity.

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