What are the Challenges in Leveraging the Immune Repertoire for Cancer Treatment?
One major challenge is the heterogeneity of tumors, which can present multiple antigens that vary between patients and even within the same tumor. Additionally, the immune system's response can be unpredictable, and some cancers develop mechanisms to evade immune detection. Finally, enhancing the immune repertoire without causing autoimmunity or other adverse effects remains a significant therapeutic challenge.
