What are the Challenges in Targeting Dynein for Cancer Therapy?
Targeting dynein for cancer therapy presents several challenges:
1. Specificity: Ensuring that dynein inhibitors selectively target cancer cells while sparing normal cells. 2. Resistance: Cancer cells can develop resistance to therapies, including dynein inhibitors. 3. Side Effects: Dynein is involved in numerous essential cellular functions, so inhibiting it can lead to significant side effects.
