What are the Mechanisms by which Dynein Influences Cancer Progression?
There are several mechanisms through which dynein can influence cancer progression:
1. Chromosome Segregation: Dynein is essential for the correct segregation of chromosomes. Errors in this process can lead to aneuploidy, contributing to tumorigenesis. 2. Cellular Signaling: Dynein is involved in the transport of various signaling molecules, including those in pathways such as Wnt and MAPK, which are often dysregulated in cancer. 3. Intracellular Transport: Dynein helps in the intracellular transport of organelles and vesicles, impacting cellular metabolism and survival, which are crucial in cancer cells.
