What are the Challenges in Targeting Efflux Pumps for Cancer Therapy?
Targeting efflux pumps for cancer therapy presents several challenges. One major issue is the redundancy and overlapping substrate specificity among different efflux pumps, which makes it difficult to inhibit a single pump without affecting others. Additionally, the development of resistance to efflux pump inhibitors themselves is a significant concern. Finally, the heterogeneity of cancer means that a one-size-fits-all approach is unlikely to be effective.
