What Molecular Mechanisms Regulate Efflux Pump Activity?
The activity of efflux pumps is regulated by multiple molecular mechanisms, including gene amplification, post-transcriptional modifications, and epigenetic changes. Additionally, the tumor microenvironment can influence the expression and function of efflux pumps. For instance, hypoxic conditions and inflammatory cytokines within the tumor microenvironment can upregulate efflux pump expression.
