What are the challenges in targeting enzyme expression in cancer?
Despite the potential of targeting enzyme expression, several challenges exist. One major issue is the off-target effects of enzyme inhibitors, which can lead to toxicity and adverse reactions. Additionally, cancer cells can develop resistance to enzyme-targeted therapies, necessitating the development of combination therapies and novel inhibitors. Furthermore, the heterogeneity of tumors means that enzyme expression can vary greatly between patients, complicating the design of one-size-fits-all treatments.
