What are the Challenges in Targeting Ferroptosis for Cancer Therapy?
Despite its potential, several challenges must be addressed. One significant obstacle is the identification of predictive biomarkers to determine which cancers are most susceptible to ferroptosis. Additionally, the development of specific and potent ferroptosis inducers with acceptable toxicity profiles is essential. Understanding the complex interplay between ferroptosis and other cell death pathways will also be crucial for optimizing therapeutic strategies.
