What are the Challenges in Targeting Integrins for Cancer Therapy?
There are several challenges associated with targeting integrins in cancer therapy:
- Redundancy and Compensation: The presence of multiple integrins with overlapping functions can lead to compensatory mechanisms that reduce the efficacy of targeted therapies. - Tumor Heterogeneity: Variability in integrin expression among different tumors and even within the same tumor can complicate the development of effective treatments. - Side Effects: Integrins are also expressed in normal tissues, raising the potential for off-target effects and toxicity.
