What Role Do Integrins Play in Tumor Angiogenesis?
Integrins such as αvβ3 and αvβ5 are critical mediators of angiogenesis. They facilitate endothelial cell migration and survival, enabling the formation of new blood vessels that supply nutrients and oxygen to growing tumors. Inhibiting these integrins has been shown to reduce angiogenesis and tumor growth in various preclinical models.
