What are the Challenges in Targeting Microtubules in Cancer Treatment?
One of the primary challenges in targeting microtubules is the development of drug resistance. Cancer cells can develop mechanisms to evade the effects of microtubule-targeting agents, such as:
Efflux pumps: Increase the expulsion of drugs from cancer cells, reducing their efficacy. Tubulin mutations: Alter drug-binding sites, decreasing drug effectiveness. Alternative pathways: Cancer cells may activate alternative pathways to maintain cell division and survival.
