Despite the potential benefits, there are several challenges in targeting MRPs:
1. Specificity: Achieving selective inhibition of MRPs without affecting other ABC transporters is difficult, as many inhibitors lack specificity. 2. Toxicity: Inhibiting MRPs can lead to toxicity in normal tissues, as these proteins play vital roles in the physiological efflux of endogenous substrates. 3. Compensatory Mechanisms: Cancer cells may upregulate other resistance mechanisms in response to MRP inhibition, reducing the effectiveness of this strategy.
