Several MRPs are particularly relevant in the context of cancer:
- MRP1 (ABCC1): Widely studied for its role in conferring resistance to anthracyclines, vinca alkaloids, and epipodophyllotoxins. - MRP2 (ABCC2): Associated with resistance to platinum-based drugs and methotrexate. - MRP3 (ABCC3): Linked to resistance against etoposide and other anticancer drugs. - MRP4 (ABCC4) and MRP5 (ABCC5): These proteins are involved in the efflux of nucleoside analogs and are implicated in resistance to chemotherapy agents like 6-mercaptopurine and thioguanine.
