Multidrug resistance proteins (MRPs) are a family of proteins known for their role in the efflux of diverse substrates, including drugs, from cells. These proteins belong to the ATP-binding cassette (ABC) transporter family, which utilizes the energy derived from ATP hydrolysis to transport substrates across cellular membranes. In the context of cancer, MRPs are significant because they can export anticancer drugs out of tumor cells, leading to multidrug resistance (MDR).
