What are the challenges in targeting mTOR for cancer treatment?
Several challenges exist in targeting mTOR for cancer therapy: 1. Resistance: Cancer cells can develop resistance to mTOR inhibitors through feedback loops and mutations. 2. Toxicity: Long-term inhibition of mTOR can lead to significant side effects, including immunosuppression and metabolic disturbances. 3. Specificity: Achieving selective inhibition of cancer cells without affecting normal cells remains a significant hurdle.
