What are the Challenges in Targeting Ras Dimerization?
Despite the promising therapeutic potential, there are several challenges in targeting Ras dimerization:
Specificity: Developing inhibitors that specifically target Ras dimers without affecting normal Ras functions is challenging. Resistance: Cancer cells may develop resistance mechanisms to Ras dimerization inhibitors. Delivery: Efficient delivery of therapeutic agents to tumor cells while minimizing off-target effects remains a significant hurdle.
