What are the Challenges in Targeting the AKT Pathway?
One of the significant challenges in targeting the AKT pathway is the potential for feedback activation and resistance mechanisms. Cancer cells can develop compensatory pathways to bypass the inhibition of AKT signaling. Additionally, the pathway's involvement in normal cellular functions poses a risk of off-target effects and toxicity. Therefore, a detailed understanding of the pathway's regulation and context-specific roles is crucial for developing effective therapies.
