What are the Challenges in Targeting TNF Receptor for Cancer Therapy?
One major challenge is the pleiotropic effects of TNF. Because TNF can trigger both pro-tumorigenic and anti-tumorigenic pathways, targeting it can have unpredictable outcomes. Another issue is the systemic nature of TNF inhibition, which can lead to generalized immune suppression and increase susceptibility to infections. Therefore, therapies must be carefully designed to balance these effects.
