The Tumor Necrosis Factor (TNF) Receptor is a cell surface receptor that binds to TNF, a cytokine involved in systemic inflammation and the acute phase response. TNF receptors are crucial in regulating immune cells, including their survival, proliferation, differentiation, and death. Two primary receptors bind TNF: TNFR1 (TNF Receptor 1) and TNFR2 (TNF Receptor 2).