What Are the Challenges in Targeting Transcription Factors?
Despite their potential, targeting transcription factors presents several challenges:
Specificity: Transcription factors often have multiple target genes and interact with various co-factors, making it difficult to achieve specificity without off-target effects. Delivery: Effective delivery of therapeutic agents, such as siRNA or decoy oligonucleotides, to cancer cells remains a significant hurdle. Resistance: Cancer cells can develop resistance to therapies targeting transcription factors, necessitating combination therapies or novel approaches.
