Which Transcription Factors Are Commonly Implicated in Cancer?
Several transcription factors are frequently associated with cancer. For example:
Myc: A transcription factor involved in cell cycle progression, apoptosis, and cellular transformation. Overexpression of Myc is found in many types of cancer. p53: Known as the "guardian of the genome," p53 plays a key role in regulating the cell cycle and apoptosis. Mutations in the p53 gene are common in various cancers. NF-κB: Involved in immune response, inflammation, and cell survival. Aberrant activation of NF-κB is linked to cancer progression and resistance to therapy. STAT3: A transcription factor activated by cytokines and growth factors, promoting cell growth and survival. Constitutive activation of STAT3 is observed in multiple cancers. HIF-1α: Regulates responses to hypoxia, promoting angiogenesis and metabolic adaptation. Overexpression of HIF-1α is seen in solid tumors.
