How Can Targeting Transcription Factors Be a Therapeutic Strategy?
Given their central role in cancer biology, transcription factors represent attractive targets for cancer therapy. Strategies to target transcription factors include:
Small molecule inhibitors: Designed to disrupt the interaction between transcription factors and DNA or their co-factors. RNA interference (RNAi): Utilizes small interfering RNA (siRNA) or short hairpin RNA (shRNA) to knock down the expression of specific transcription factors. CRISPR/Cas9: Genome editing technology to knock out or modify genes encoding transcription factors. Decoy oligonucleotides: Synthetic DNA sequences that mimic transcription factor binding sites, sequestering the transcription factors and preventing them from binding to their target genes.
