What are the Challenges in Targeting Tumor Vasculature?
While targeting tumor vasculature holds promise, there are several challenges. One major issue is the development of resistance to anti-angiogenic therapies. Tumors can adapt by upregulating alternative pro-angiogenic pathways or by increasing their invasiveness to circumvent the blocked pathways. Additionally, the heterogeneity of tumor vasculature means that a one-size-fits-all approach may not be effective for all cancers.
