What are the Clinical Implications of Genomic Instability?
Understanding genomic instability has significant clinical implications:
Diagnosis: Genomic instability markers can help in the early detection of cancer. Prognosis: The extent of genomic instability can indicate the aggressiveness of a tumor. Therapeutic Targets: Targeting specific pathways involved in genomic instability, such as DNA repair mechanisms, can provide new treatment strategies. For example, PARP inhibitors are used to exploit deficiencies in homologous recombination repair in certain cancers. Personalized Medicine: Genomic profiling of tumors can guide personalized treatment plans based on specific genetic alterations.
