Genomic instability is a hallmark of cancer. It involves an increased tendency for genome alterations such as mutations, chromosomal rearrangements, and aneuploidy. These changes can lead to the activation of oncogenes or the inactivation of tumor suppressor genes, driving the initiation and progression of cancer. Genomic instability allows for the rapid evolution of cancer cells, enabling them to adapt to selective pressures like immune surveillance and treatment.
