What Are the Clinical Implications of Understanding Gene Regulatory Networks in Cancer?
Understanding GRNs in cancer can lead to the identification of novel biomarkers for early detection and prognosis. It can also aid in the development of targeted therapies. For instance, inhibitors targeting the PI3K/AKT/mTOR signaling pathway, which is often dysregulated in cancer, have shown promise in clinical trials. Additionally, drugs that modulate epigenetic marks, such as DNA methyltransferase inhibitors, are being explored as potential cancer therapies.
