What Are the Challenges in Studying Gene Regulatory Networks in Cancer?
Studying GRNs in cancer involves several challenges. The heterogeneity of tumors means that GRNs can vary significantly between different cancer types and even within different regions of the same tumor. Additionally, the dynamic nature of GRNs requires time-resolved data, which can be difficult to obtain. Technical limitations in single-cell sequencing and the need for more sophisticated computational tools also pose challenges.
