What Role Do Transcription Factors Play in Cancer?
Transcription factors are proteins that bind to specific DNA sequences to control the transcription of genetic information from DNA to mRNA. In cancer, transcription factors can become overexpressed, mutated, or inappropriately activated. For example, the transcription factor MYC is often overexpressed in various cancers, driving the expression of genes that promote cell proliferation and survival. Similarly, NF-κB plays a significant role in promoting inflammation, which is a known contributor to cancer progression.
