What are the Common Mutations in the PI3K Pathway?
Mutations in the PI3K pathway are frequently observed in various cancers. One of the most common mutations is in the PIK3CA gene, which encodes the p110α catalytic subunit of PI3K. Mutations in PIK3CA are found in breast, colorectal, and other cancers. Another important mutation occurs in the PTEN gene, which encodes a phosphatase that negatively regulates the PI3K pathway. Loss of PTEN function leads to increased PI3K activity and cancer progression.
