What Are the Future Directions in 2-Hydroxyglutarate Research?
Future research is likely to focus on several areas, including: 1. Developing more effective and specific inhibitors for various IDH mutations. 2. Understanding the broader impact of 2HG on cellular metabolism and the tumor microenvironment. 3. Investigating combination therapies that target 2HG in conjunction with other therapeutic agents to enhance treatment efficacy. 4. Identifying and validating additional biomarkers associated with 2HG and its downstream effects to better stratify patients and tailor therapies.
