2-Hydroxyglutarate (2HG) is a metabolite that is produced in cells under specific conditions. Normally, it is found in negligible amounts; however, its levels can become significantly elevated due to mutations in certain enzymes, particularly isocitrate dehydrogenase (IDH). There are two enantiomers of 2HG: D-2-hydroxyglutarate and L-2-hydroxyglutarate, each produced via different metabolic pathways and implicated in various diseases, including cancer.
