Carcinomas: Cancers that originate in the skin or in tissues that line or cover internal organs. Sarcomas: Cancers that originate in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemias: Cancers that originate in blood-forming tissue such as the bone marrow and cause large numbers of abnormal blood cells to be produced and enter the blood. Lymphomas and multiple myeloma: Cancers that originate in the cells of the immune system. Central nervous system cancers: Cancers that originate in the tissues of the brain and spinal cord.