The activity of c-Myc is regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms. Transcriptionally, c-Myc expression can be influenced by growth factors and signaling pathways such as the Wnt/β-catenin and MAPK pathways. Post-transcriptionally, c-Myc mRNA stability and translation are regulated by RNA-binding proteins and microRNAs. Post-translationally, c-Myc protein stability is controlled by ubiquitination and phosphorylation, affecting its degradation by the proteasome.
