What are the Mechanisms of PRC Dysregulation in Cancer?
Several mechanisms contribute to the dysregulation of PRCs in cancer: 1. Genetic Mutations: Mutations in genes encoding PRC components or their regulators can lead to loss or gain of function, contributing to cancer development. 2. Epigenetic Alterations: Abnormal epigenetic changes, such as DNA methylation patterns, can affect the recruitment and activity of PRCs, leading to inappropriate gene silencing. 3. Transcriptional Changes: Overexpression of PRC components like EZH2 can occur due to transcriptional upregulation, often driven by oncogenic signaling pathways.
