RNR activity is regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational modifications. It is also subject to allosteric regulation by nucleotides. p53, a well-known tumor suppressor, can downregulate RNR in response to DNA damage, thereby halting cell cycle progression to allow for DNA repair. Conversely, oncogenes like c-Myc can upregulate RNR to promote cell proliferation.
