How Does RNR Contribute to Chemotherapy Resistance?
Cancer cells can develop resistance to chemotherapy drugs that target DNA synthesis. RNR is often implicated in this resistance because altering its activity can help cancer cells survive the cytotoxic effects of these drugs. For instance, hydroxyurea, a common chemotherapeutic agent, targets RNR to inhibit DNA synthesis. However, cancer cells can adapt by increasing RNR expression or altering its regulatory mechanisms, thereby diminishing the drug's efficacy.
