Why is Ribonucleotide Reductase Important in Cancer?
In cancer, cell proliferation is uncontrolled. The elevated demand for DNA synthesis in rapidly dividing cancer cells makes RNR a vital enzyme for tumor growth. Overexpression or dysregulation of RNR is often observed in various cancers, linking it to tumorigenesis and cancer progression. The enzyme's activity is tightly regulated by the cellular environment, and any imbalance can lead to genomic instability, a hallmark of cancer.
