What are the Therapeutic Implications of circRNA in Cancer?
Targeting circRNAs offers a novel therapeutic approach for cancer treatment. Strategies to modulate circRNA levels in cancer cells include: 1. Antisense Oligonucleotides (ASOs): ASOs can be designed to specifically bind and degrade circRNAs, thereby reducing their levels in cancer cells. 2. CRISPR/Cas9 Technology: This gene-editing tool can be used to disrupt the formation of circRNAs by targeting back-splice junctions. 3. miRNA Mimics/Inhibitors: Since some circRNAs function by sponging miRNAs, restoring the levels of these miRNAs using mimics or inhibitors can counteract the effects of circRNAs in cancer.
