What Are the Therapeutic Implications of Targeting G Proteins in Cancer?
Given their central role in cell signaling, G proteins and their associated pathways are attractive targets for cancer therapy. Inhibitors targeting GPCRs or specific subunits of G proteins can potentially disrupt aberrant signaling in cancer cells. For instance, drugs targeting the hedgehog signaling pathway, which involves GPCR-mediated signaling, have shown efficacy in treating basal cell carcinoma. Furthermore, research into G protein-coupled receptor antagonists and modulators continues to expand the therapeutic arsenal against various cancers.
