Treatment for GVHD often involves the use of immunosuppressive drugs to reduce the immune system's attack on the host tissues. Common medications include corticosteroids, calcineurin inhibitors (such as cyclosporine and tacrolimus), and other immunosuppressive agents like methotrexate and mycophenolate mofetil. In more severe cases, additional treatments such as extracorporeal photopheresis (ECP) or targeted therapies may be used.