What are TPO-Mimetics and Their Role in Cancer Therapy?
TPO-mimetics are synthetic agents designed to mimic the action of natural TPO. They bind to the c-Mpl receptor and stimulate platelet production. These agents, such as romiplostim and eltrombopag, are used to treat thrombocytopenia in various settings, including cancer patients undergoing myelosuppressive therapy. By increasing platelet counts, TPO-mimetics can reduce the need for platelet transfusions and minimize bleeding risks, thereby improving patient outcomes.